DONET M800SR
$49.00$69.00
Doxofylline 800mg SR + Montelukast 10mg
DOXOFYLLINE
Is a novel xanthine bronchodilator and anti-inflammatory.
It inhibits phosphodiesterase activity thus increasing cAMP level hence promoting smooth muscle
relaxation.
Doxofylline is a methylxanthine derivative used in chronic obstructive pulmonary disease
(COPD), asthma, and bronchospasms.
Description
Doxofylline is a methylxanthine derivative with the presence of a dioxolane group in
position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy
to theophylline but with significantly fewer side effects in animal and human studies. In
contrast with other xanthine derivatives, doxofylline does not significantly bind to
adenosine alpha-1 or alpha-2 receptors and lacks stimulating effects. Decreased affinity for
adenosine receptors may account for the better safety profile of doxofylline compared to
theophylline . Unlike theophylline, doxofylline does not affect calcium influx and does not
antagonize the actions of calcium channel blockers which could explain reduced cardiac
adverse reactions associated with the drug . The anti-asthmatic effects of doxophylline are
mediated by other mechanisms, primarily through inhibiting the activities of the
phosphodiesterase (PDE) enzyme.
Additional information
| color | White |
|---|---|
| warranty | 5. years |
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